New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
نویسندگان
چکیده
New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared characterized. They used as excipients to increase the solubility of two model oral drugs BCS class II, ibuprofen piroxicam. With only 0.2 mol% (≈100 mM) [N4 1 2OH]2[C4H4O4], increases over 40-fold 2-fold for ibuprofen, when compared with parent drug water phosphate buffer solution (PBS) 0.01M pH=7.4, respectively. 0.02 2OH]2[C4H4O4] it is possible achieve a ≈600 mg/L, in 5 min at 37°C, corresponding one dose that an adult can take. Piroxicam also showed 20-fold 1.5-fold PBS respectively, 2OH]2[C5H6O4]. The lipophilicity (logP) both decreased presence these compounds. cytotoxicity profile several ILs was determined, all except 2OH]2[C3H2O4] have IC50 higher than 100 mM fibroblasts L929 cells.
منابع مشابه
Modeling the Solubility of Acid Gases in Ionic Liquids
In this work, the PC-SAFT equation of state (EoS) has been used to model the solubility of acid gases (CO2 and H2S) in two imidazolium-based ionic liquids (ILs) ([C8-mim][PF6] and [C8-mim][Tf2N]). Parameters of pure ILs were estimated using experimental densities. Two strategies were considered to model densities of pure ILs. In strategy 1, ILs were modeled as nonassociating compounds and in st...
متن کاملThe Solubility of Gases in Ionic Liquids
In this Perspective, we provide a detailed discussion of the techniques and methods used for determining the solubility of gases in ionic liquids (ILs). This includes various experimental measurement techniques, equation of state (EOS) modeling, and predictive molecular-based modeling. Many of the key papers from the past 15 years are discussed and put into the context of the latest advances in...
متن کاملThe Solubility Parameters of Ionic Liquids
The Hildebrand's solubility parameters have been calculated for 18 ionic liquids from the inverse gas chromatography measurements of the activity coefficients at infinite dilution. Retention data were used for the calculation. The solubility parameters are helpful for the prediction of the solubility in the binary solvent mixtures. From the solubility parameters, the standard enthalpies of vapo...
متن کاملmodeling the solubility of acid gases in ionic liquids
in this work, the pc-saft equation of state (eos) has been used to model the solubility of acid gases (co2 and h2s) in two imidazolium-based ionic liquids (ils) ([c8-mim][pf6] and [c8-mim][tf2n]). parameters of pure ils were estimated using experimental densities. two strategies were considered to model densities of pure ils. in strategy 1, ils were modeled as nonassociating compounds and in st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of ionic liquids
سال: 2021
ISSN: ['2772-4220']
DOI: https://doi.org/10.1016/j.jil.2021.100003